Headed by the Executive Officer, Corrina Greenwood, the U21 HSG Secretariat is responsible for the operational and strategic management of the group. The Secretariat also manages the U21 HSG's budget and communications. The U21 Health Sciences Group Secretariat is currently hosted by the College of Medical and Dental Sciences, University of Birmingham, UK. It was previously hosted by the University of British Columbia (2011-2017), Tecnologico de Monterrey (2010-2011), and the University of Melbourne (2002-2010).

For any queries about the U21 HSG, please contact u21health@gmail.com.